The Bulldogs (11-8, 1-5) took a 4-1 lead after five innings and held off a late rally to slip away with the victory.
Chris Andrepont earned his sixth victory of the season, giving up three runs on 10 hits and three walks. He struck out three.
Blaise LeJeune had two hits for Iota and drove in three runs. Trenton Pickett had one hit and one run driven in.
Doug Greenman and Collin Todd each had two hits for St. Louis.
Iota will be in action again Tuesday when they take on Jennings at 6 o’clock. The game will be played in Eunice at LSUE’s Bengal Stadium.