State Police said David Bollinger, 61, of Montgomery, Ala., was north-bound when Genelia Manuel, 74, failed to yield and began to turn left into a driveway from the south-bound lane about 1:30 p.m.
The collision occurred on La. 13 south of La. 374 in Evangeline Parish.
Manuel's car struck the motorcycle in the middle of the north-bound lane.
Bollinger was completely ejected from the bike and died at the scene, police said.
Manuel was taken to Acadian Medical Center in Eunice. A report on her condition was not immediately available.
Investigation into the accident continues.